Label-free Sensing of Main Protease Activity of SARS-CoV-2 with an Aerolysin NanoporeArticle Published on 2022-11-022022-11-15 Journal: Chemistry, an Asian journal [Category] SARS, 치료기술, [키워드] activity acute respiratory syndrome amplification Biomarker cleavage cleaved Concentration conserved coronavirus Critical diagnostic enzyme events exhibited expand M pro MPro Nanopore peptide produced protease Replication SARS-CoV-2 sensitivity sensors. translocated viruses [DOI] 10.1002/asia.202200747 PMC 바로가기
Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascadeShort communication Published on 2022-04-012022-10-05 Journal: Biochemical and Biophysical Research Communication [Category] 신약개발, [키워드] acute lung injury ameliorated attenuate cascade cytoplasmic drug escitalopram HDAC4 IC50 infiltration Inflammatory responses inhibited inhibiting investigated Lung injury mice morbidity and mortality neutrophil NF-κB signaling nucleus p65 pathway pro-inflammatory cytokine promoted pulmonary injury reduced SIK2 translocated Treatment triggered [DOI] 10.1016/j.bbrc.2022.02.015 [Article Type] Short communication
Absence of YhdP, TamB, and YdbH leads to defects in glycerophospholipid transport and cell morphology in Gram-negative bacteriaYHDP, TAMB 및 YDBH의 부재는 그람 음성 박테리아에서 글리세로 포스 포스 폴리티드 수송 및 세포 형태의 결함으로 이어진다Research Article Published on 2022-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulate adjust anterograde antibiotic Antibiotic resistance asymmetric Bacterial balance biosynthetic biosynthetic pathways Cell cell envelope cell lysis changes in characterized component contribute Critical Defense effective foundation gram Gram-negative bacteria homeostasis homologues inner leaflet leads lipopolysaccharide LPS maintain maintaining membrane membrane vesicles morphology mutant offer outer membrane overexpression pathway phenotype Phenotypes Protein provide reducing rescued restored sensitivity shedding the cell Therapies Threats translocated Transport understanding vesicles viability [DOI] 10.1371/journal.pgen.1010096 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophagesACE2 발현 미립자에 의한 SARS-CoV-2 치료 효과는 폐포 대식세포의 산화된 콜레스테롤 증가 엔도솜 pH로 설명Article Published on 2022-01-042022-09-12 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] A549 addition Administered alveolar macrophage Alveolar macrophages anatomical cell-derived microparticle cholesterol cross-talk decrease Degradation Effect Efficacy emerging respiratory virus Endosomal acidification endosomal pH Endosomes explained feasibility feature highlight immune system impairing inhibit lung lysosomal lysosome Lysosomes membranes Microparticle microparticles oxidized phenotype proinflammatory Regulation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 treatment SARS-CoV-2-infected patient Side effects therapeutic therapy translocated treat Treatment viral infection [DOI] 10.1038/s41423-021-00813-6 PMC 바로가기 [Article Type] Article
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagySARS-CoV-2 ORF10은 미토파지를 통해 MAVS를 분해하여 항바이러스 선천 면역 반응을 억제합니다.Article Published on 2022-01-012022-09-11 Journal: Cellular and Molecular Immunology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] accumulation Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral signaling autophagy binding blocked caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Degradation expressed expression facilitated Frame humans IFN-I IFN-I signaling IFN-stimulated genes induce inhibit inhibited innate immune innate immune response Interaction knockdown MAVS mechanism Mitochondria mitochondrial mitophagy. morbidity and mortality NIX Open reading frame ORF10 overexpression pandemic pathway promoted Protein receptor SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus suppresse suppressed target translocated type I interferon viral genes viral replication [DOI] 10.1038/s41423-021-00807-4 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid dropletsResearch Article Published on 2021-11-222022-10-31 Journal: Febs Letters [Category] COVID-19, [키워드] A549 A549 cell approach association biological processe blocked cancer cell Cancer cells cells droplet epithelial exhibited G3BP1 G3BP2 Heat shock human lung interact Interaction investigated liquid–liquid phase separation mitoxantrone N protein NCAP nucleocapsid nucleocapsid protein oxidative oxidative stress PKR Protein provide RNA RNA degradation RNase SARS‐CoV‐2 SARS‐CoV‐2 SILAC Stress stress granule stress granules translocated Treatment undergo USP10 viral factory viral infection YTHDF3 [DOI] 10.1002/1873-3468.14229 PMC 바로가기 [Article Type] Research Article
Disease Risk and Conservation Implications of Orangutan TranslocationsVeterinary Science Published on 2021-11-122022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] applied catastrophic collected data conservation Contact COVID-19 COVID-19 pandemic decrease disease disease risk disease transmission effort Endangered equipment Human human diseases Identified Impact IMPROVE individual Indonesia interactions likelihood management measure occur orangutan other disease Outbreaks pathogen Population populations Practitioner Protective reinforcement reintroduction Release released risk study period Surveillance susceptible translocated translocation transmitted while wildlife [DOI] 10.3389/fvets.2021.749547 PMC 바로가기 [Article Type] Veterinary Science
Concise Update on Genomics of COVID-19: Approach to Its latest Mutations, Escalated Contagiousness, and Vaccine ResistanceReview Article Published on 2021-09-152022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] acute respiratory distress Amino acid calreticulin canonical cause caused Cell changes in Chinese Clinical features complex connection coronavirus COVID-19 COVID-19 pandemic diagnostics Epidemiology genomic Genomics genomics of virus help histocompatibility complex Host hydrophobicity immune system Infectious disease inhibit intrinsic less membrane MHC-I Modification molecular multifunctional N-linked glycosylation Novel coronavirus novel coronavirus disease Nsp7 nucleus oligosaccharide outlined pandemic positive Protein proteomics Replication rate resistance response RNA genome SARS-CoV-2 sequence STAT structures syndrome transcription factor transfer translocated Treatment Vaccine development viral outbreak Viral protein virus [DOI] 10.1055/s-0041-1725143 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 envelope protein topology in eukaryotic membranes1001 Published on 2020-09-092022-10-29 Journal: Open Biology [Category] COVID-19, SARS, [키워드] biochemical C-terminus component contribute coronavirus cytoplasmic defined E protein envelope protein eukaryotic functional Host Interaction mammalian cells membrane membrane insertion membrane protein N-terminus new SARS-CoV-2 pathogenesis of SARS-CoV-2 protein topology SARS-CoV-2 SARS-CoV-2 envelope Sequence conservation similarities Topology translocated virus [DOI] 10.1098/rsob.200209 PMC 바로가기 [Article Type] 1001
Bacterial sensing: A putative amphipathic helix in RsiV is the switch for activating σ V in response to lysozyme박테리아 감지: RsiV의 추정되는 양친매성 나선은 리소자임에 대한 반응으로 σ V를 활성화하는 스위치입니다.Research Article Published on 2018-07-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activating Activation addition Bacillus Bacillus subtilis Bacteria binding changes in charged residue cleavage cleavage site cleave cleaved Degradation Disruption domain Evidence Factor Firmicute firmicutes function Gene Expression hydrophobic inactive indicated inhibitor lysozyme membrane molecular peptidase PROTECT regulated required resistance genes respond responsible signal substrate substrates translocated Trigger triggering triggers unique [DOI] 10.1371/journal.pgen.1007527 PMC 바로가기 [Article Type] Research Article